Corona 2 crack3/22/2023 COVID-19 disease severity has been linked to an immune dysregulation, leading to a cytokine storm. 1: Gingival inflammationīleeding and inflammation in oral tissue have been suggested to be a result of a generalized increase in inflammation due to elevated levels of cytokines and interleukins initiated by the SARS CoV-2 virus. This article will briefly review the top five oral manifestations associated with COVID-19. 3 Namely, these include the ACE2 receptor and an enzyme called TMPRSS (transmembrane protease, serine 2), which allows the virus to fuse its membrane with that of the host cell and slip inside. 2 A new preprint study found that, compared with other oral tissues, cells of the salivary glands, tongue, and tonsils carry the most RNA linked to proteins that the SARS-CoV-2 virus needs to infect cells. The ACE2 receptor has been well-documented to be the target receptor of the SARS-CoV-2 virus and the portal of entry into the human cell. In a New York Times article, survivors of COVID-19 who have had the disease for weeks to months-termed “long haulers”-describe oral problems they’re experiencing such as “teeth falling out, sensitive gums, teeth turning grey, and teeth cracking.” 1 Although many physicians continue to question the direct link between SARS-CoV-2 and oral disease, studies suggest that the mouth might be the most vulnerable area to this virus due to the abundance of the ACE2 (angiotensin converting enzyme) receptor in oral tissue.
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